Study analyses effects of ultra-processed foods on the body

Ultra-processed foods (UPFs) are industrially altered products - like soda, snacks and processed meats - packed with additives and stripped of nutrients.

Hundreds of new ingredients, previously unknown to the human body, now make up nearly 60 per cent of the average adult’s diet, and almost 70 per cent of children’s diets in the United States.

These products reduce nutritional value, extend shelf life, and tend to increase how much people consume.

In the US, UPFs account for about 60 per cent of daily calorie intake. High consumption of these foods has been linked to greater risks of obesity, cancer, metabolic and cardiovascular diseases, mental health issues, and even premature death.

New research from Florida Atlantic University’s Charles E. Schmidt College of Medicine shows that people who consume the most UPFs have significantly higher levels of high-sensitivity C-reactive protein (hs-CRP), a sensitive marker of inflammation and a strong predictor of cardiovascular disease.

Until now, there has been limited data from nationally representative US populations on the link between UPF intake and hs-CRP levels.

Results of the study, published in The American Journal of Medicine, show that participants consumed a median of 35 per cent of their daily calories from UPFs, ranging from just 0 per cent to 19 per cent in the lowest group to 60 per cent to 79 per cent in the highest.

After accounting for factors like age, gender, smoking, physical activity and other health indicators, researchers found that individuals in the highest UPF intake group (60 per cent to 79 per cent of daily calories) had an 11 per cent higher likelihood of elevated hs-CRP levels, compared to those in the lowest intake group.

Even moderate UPF consumers (40 per cent to 59 per cent) showed a 14 per cent increase in likelihood. Those with 20 per cent to 39 per cent intake had a smaller, non-significant 7 per cent increase.

The likelihood was especially high in certain groups. Adults ages 50 to 59 had a 26 per cent higher risk of elevated inflammatory markers, compared to those ages 18 to 29.

OBESITY

Obesity contributed to an 80 per cent higher risk, compared to people with a healthy weight. Current smokers also had a higher risk (17 per cent) than people who never smoked.

Interestingly, individuals who reported no physical activity did not have a statistically significant increase in risk compared to those who met activity guidelines.

“These findings, based on a large and nationally representative sample of US adults, clearly show that people who consume the highest amounts of ultra-processed foods have significantly higher levels of high-sensitivity C-reactive protein, a key marker of inflammation,” said Allison Ferris, senior author, professor and chair of the FAU Department of Medicine.

“These results carry important implications, not only for clinical practice and public health strategies, but also for future research aimed at understanding and reducing the health risks associated with ultra-processed food consumption,” added Allison.

Researchers analysed data from 9,254 U.S. adults in the National Health and Nutrition Examination Survey, including diet, hs-CRP and other health factors.

UPF intake was measured as a percentage of total calories and grouped into four levels. They used statistical methods, including logistic regression, to examine the link between UPF consumption and inflammation.

“C-reactive protein is produced by the liver, and the hs-CRP protein test is a simple, affordable and highly sensitive measure of inflammation, as well as a reliable predictor of future cardiovascular disease,” said Charles Hennekens, senior academic advisor, Schmidt College of Medicine.

“We believe that healthcare professionals may wish to consider actively engaging with their patients about the risks of UPFs and benefits of increasing whole food consumption,” added Charles.

Drawing a parallel to the history of tobacco, the authors note that it took decades for mounting evidence and the efforts of progressive health officials to lead to policies discouraging cigarette use. They believe a similar trajectory is likely for UPFs, with growing awareness eventually driving meaningful public health action.

ANI